Spatial & Functional
Genomics Affinity Group

SFG Publications

Intersections and clinical translations of diabetes mellitus with cancer promotion, progression and prognosis.

Schwartz SS, Grant SFA, Herman ME.

Postgraduate Medicine, 2019.

PMID: 31419922

T follicular helper cells in human efferent lymph retain lymphoid characteristics

Vella LA, Buggert M, Manne S, Herati RS, Sayin I, Kuri-Cervantes L, Bukh Brody I, O'Boyle KC, Kaprielian H, Giles JR, Nguyen S, Muselman A, Antel JP, Bar-Or A, Johnson ME, Canaday DH, Naji A, Ganusov VV, Laufer TM, Wells AD, Dori Y, Itkin MG, Betts MR, Wherry EJ.

J Clin Invest. 2019;129(8):3185–3200.

PMID: 31264971

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi, Felix R. Day, Øyvind Helgeland, Charles Laurin, Jonas Bacelis, Shouneng Peng, Ke Hao, Bjarke Feenstra, Andrew R. Wood, Anubha Mahajan, Jessica Tyrrell, Neil R. Robertson, N. William Rayner, Zhen Qiao, Gunn-Helen Moen, Marc Vaudel, Carmen J. Marsit, Jia Chen, Michael Nodzenski, Theresia M. Schnurr, Mohammad H. Zafarmand, Jonathan P. Bradfield, Niels Grarup, Marjolein N. Kooijman, Ruifang Li-Gao, Frank Geller, Tarunveer S. Ahluwalia, Lavinia Paternoster, Rico Rueedi, Ville Huikari, Jouke-Jan Hottenga, Leo-Pekka Lyytikäinen, Alana Cavadino, Sarah Metrustry, Diana L. Cousminer, Ying Wu, Elisabeth Thiering, Carol A. Wang, Christian T. Have, Natalia Vilor-Tejedor, Peter K. Joshi, Jodie N. Painter, Ioanna Ntalla, Ronny Myhre, Niina Pitkänen, Elisabeth M. van Leeuwen, Raimo Joro, Vasiliki Lagou, Rebecca C. Richmond, Ana Espinosa, Sheila J. Barton, Hazel M. Inskip, John W. Holloway, Loreto Santa-Marina, Xavier Estivill, Wei Ang, Julie A. Marsh, Christoph Reichetzeder, Letizia Marullo, Berthold Hocher, Kathryn L. Lunetta, Joanne M. Murabito, Caroline L. Relton, Manolis Kogevinas, Leda Chatzi, Catherine Allard, Luigi Bouchard, Marie-France Hivert, Ge Zhang, Louis J. Muglia, Jani Heikkinen, EGG Consortium, Camilla S. Morgen, Antoine H. C. van Kampen, Barbera D. C. van Schaik, Frank D. Mentch, Claudia Langenberg, Jian’an Luan, Robert A. Scott, Jing Hua Zhao, Gibran Hemani, Susan M. Ring, Amanda J. Bennett, Kyle J. Gaulton, Juan Fernandez-Tajes, Natalie R. van Zuydam, Carolina Medina-Gomez, Hugoline G. de Haan, Frits R. Rosendaal, Zoltán Kutalik, Pedro Marques-Vidal, Shikta Das, Gonneke Willemsen, Hamdi Mbarek, Martina Müller-Nurasyid, Marie Standl, Emil V. R. Appel, Cilius E. Fonvig, Caecilie Trier, Catharina E. M. van Beijsterveldt, Mario Murcia, Mariona Bustamante, Sílvia Bonas-Guarch, David M. Hougaard, Josep M. Mercader, Allan Linneberg, Katharina E. Schraut, Penelope A. Lind, Sarah E. Medland, Beverley M. Shields, Bridget A. Knight, Jin-Fang Chai, Kalliope Panoutsopoulou, Meike Bartels, Friman Sánchez, Jakob Stokholm, David Torrents, Rebecca K. Vinding, Sara M. Willems, Mustafa Atalay, Bo L. Chawes, Peter Kovacs, Inga Prokopenko, Marcus A. Tuke, Hanieh Yaghootkar, Katherine S. Ruth, Samuel E. Jones, Po-Ru Loh, Anna Murray, Michael N. Weedon, Anke Tönjes, Michael Stumvoll, Kim F. Michaelsen, Aino-Maija Eloranta, Timo A. Lakka, Cornelia M. van Duijn, Wieland Kiess, Antje Körner, Harri Niinikoski, Katja Pahkala, Olli T. Raitakari, Bo Jacobsson, Eleftheria Zeggini, George V. Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Grant W. Montgomery, Harry Campbell, James F. Wilson, Tanja G. M. Vrijkotte, Martine Vrijheid, Eco J. C. N. de Geus, M. Geoffrey Hayes, Haja N. Kadarmideen, Jens-Christian Holm, Lawrence J. Beilin, Craig E. Pennell, Joachim Heinrich, Linda S. Adair, Judith B. Borja, Karen L. Mohlke, Johan G. Eriksson, Elisabeth E. Widén, Andrew T. Hattersley, Tim D. Spector, Mika Kähönen, Jorma S. Viikari, Terho Lehtimäki, Dorret I. Boomsma, Sylvain Sebert, Peter Vollenweider, Thorkild I. A. Sørensen, Hans Bisgaard, Klaus Bønnelykke, Jeffrey C. Murray, Mads Melbye, Ellen A. Nohr, Dennis O. Mook-Kanamori, Fernando Rivadeneira, Albert Hofman, Janine F. Felix, Vincent W. V. Jaddoe, Torben Hansen, Charlotta Pisinger, Allan A. Vaag, Oluf Pedersen, André G. Uitterlinden, Marjo-Riitta Järvelin, Christine Power, Elina Hyppönen, Denise M. Scholtens, William L. Lowe Jr, George Davey Smith, Nicholas J. Timpson, Andrew P. Morris, Nicholas J. Wareham, Hakon Hakonarson, Struan F. A. Grant, Timothy M. Frayling, Debbie A. Lawlor, Pål R. Njølstad, Stefan Johansson, Ken K. Ong, Mark I. McCarthy, John R. B. Perry, David M. Evans & Rachel M. Freathy

Nature Genetics 51, 804–814 (2019)

PMID: 31043758

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bonemineral density

Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F.A. Grant

NATURE COMMUNICATIONS | (2019)10:1260

PMID: 30890710

Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls

Diana L. Cousminer, Shana E. McCormack, Jonathan A. Mitchell, Alessandra Chesi, Joseph M. Kindler, Andrea Kelly, Benjamin F. Voight, Heidi J. Kalkwarf, Joan M. Lappe, John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel, Struan F.A. Grant

Bone, 2019.01.026

PMID: 30711642

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC.
Cell. 2018 Oct 30. pii: S0092-8674(18)31309-6. doi: 10.1016/j.cell.2018.10.001. [Epub ahead of print]

PMID: 30392958

Public resources aid diabetes gene discovery.

D.L. Cousminer and S.F.A. Grant

Nature Genetics Epub ahead of print, October 2018.

PMID: Link

First Genome Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.

D.L. Cousminer*, E. Ahlqvist*, R. Mishra*, M.K. Andersen*, A. Chesi, M.I. Hawa, A. Davis, K.M. Hodge, J.P. Bradfield, K. Zhou, V.C. Guy, M. Åkerlund, M. Wod, L.G. Fritsche, H. Vestergaard, J. Snyder, K. Højlund, A. Linneberg, A. Käräjämäki, I. Brandslund, C.E. Kim, D. Witte, E. Pettersen Sørgjerd, D.J. Brillon, O. Pedersen, H. Beck-Nielsen, N. Grarup, R.E. Pratley, M.R. Rickels, A. Vella, F. Ovalle, O. Melander, R.I. Harris, S. Varvel, V.E.R. Grill, Bone Mineral Density in Childhood Study, H. Hakonarson, P. Froguel, J.T. Lonsdale, D. Mauricio, N.C. Schloot, K. Khunti, C.J. Greenbaum, B.O. Åsvold, K.B. Yderstræde, E.R. Pearson, S. Schwartz, B.F. Voight, T. Hansen, T. Tuomi, B.O. Boehm*, L. Groop*, R.D. Leslie* and S.F.A. Grant*

Diabetes Care Epub ahead of print, September 2018 Notes: *equal contribution.

PMID: Link

Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS

Elisabetta Manduchi, Scott M. Williams, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Struan F.A. Grant, Jason H. Moore
Hum Genet. 2018 May; 137(5): 413–425. Published online 2018 May 24. doi: 10.1007/s00439-018-1893-0

PMID: 29797095

Leveraging Putative Enhancer-Promoter Interactions to Investigate Two-Way Epistasis in Type 2 Diabetes GWAS

Manduchi E, Chesi A, Hall MA, Grant SFA, Moore JH.
Pac Symp Biocomput. 2018;23:548-558.

PMID: 29218913

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