Spatial & Functional
Genomics Affinity Group

SFG Publications

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Alexessander Couto Alves1,2,*, N. Maneka G. De Silva1,*, Ville Karhunen1, Ulla Sovio3,4, Shikta Das1,5, H. Rob Taal6,7, Nicole M. Warrington8,9, Alexandra M. Lewin1,10, Marika Kaakinen11,12,13, Diana L. Cousminer14,15,16, Elisabeth Thiering17,18, Nicholas J. Timpson19,20, Tom A. Bond1, Estelle Lowry21, Christopher D. Brown22, Xavier Estivill23,24,25,26, Virpi Lindi15, Jonathan P. Bradfield28, Frank Geller29, Doug Speed30,31, Lachlan J. M. Coin1,32, Marie Loh1,21,33, Sheila J. Barton34,35, Lawrence J. Beilin36, Hans Bisgaard37, Klaus Bønnelykke37, Rohia Alili38, Ida J. Hatoum38,39,40, Katharina Schramm41,42, Rufus Cartwright1,43, Marie-Aline Charles44, Vincenzo Salerno1, Karine Clément38,44, Annique A. J. Claringbould45, BIOS Consortium, Cornelia M. van Duijn46, Elena Moltchanova47, Johan G. Eriksson48,49,50, Cathy Elks51, Bjarke Feenstra29, Claudia Flexeder17, Stephen Franks43, Timothy M. Frayling52, Rachel M. Freathy52, Paul Elliott1,53,54, Elisabeth Widén16, Hakon Hakonarson14,28,55,56, Andrew T. Hattersley52, Alina Rodriguez1,57, Marco Banterle10, Joachim Heinrich17, Barbara Heude44, John W. Holloway58, Albert Hofman6,46, Elina Hyppönen59,60,61, Hazel Inskip34,62, Lee M. Kaplan39,40, Asa K. Hedman63,64, Esa Läärä65, Holger Prokisch41,42, Harald Grallert66,67, Timo A. Lakka15,68,69, Debbie A. Lawlor19,20, Mads Melbye29,70,71, Tarunveer S. Ahluwalia37, Marcella Marinelli25,26,72, Iona Y. Millwood73,74, Lyle J. Palmer75, Craig E. Pennell8, John R. Perry51, Susan M. Ring19,20,76, Markku J. Savolainen77, Fernando Rivadeneira46,78, Marie Standl17, Jordi Sunyer24,25,26,72, Carla M. T. Tiesler17,18, Andre G. Uitterlinden46,78, William Schierding79, Justin M. O’Sullivan79,80, Inga Prokopenko11,13,63,81, Karl-Heinz Herzig82,83,84,85, George Davey Smith19,20, Paul O'Reilly1,86, Janine F. Felix6,7,46, Jessica L. Buxton87, Alexandra I. F. Blakemore88,89, Ken K. Ong51, Vincent W. V. Jaddoe6,46,†, Struan F. A. Grant14,28,55,56,†,‡, Sylvain Sebert1,21,82,†,‡, Mark I. McCarthy63,81,90,†,‡,§, Marjo-Riitta Järvelin1,21,82,84,88,91,†,‡, Early Growth Genetics (EGG) Consortium

 

Science Advances  04 Sep 2019:
Vol. 5, no. 9, eaaw3095
DOI: 10.1126/sciadv.aaw3095

PMID: https://advances.sciencemag.org/content/5/9/eaaw3095

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.

Liu X1, Helenius D2,3, Skotte L1, Beaumont RN4, Wielscher M5, Geller F1, Juodakis J6, Mahajan A7, Bradfield JP8,9, Lin FTJ10, Vogelezang S11,12,13, Bustamante M14,15,16, Ahluwalia TS17, Pitkänen N18, Wang CA19, Bacelis J20, Borges MC21,22, Zhang G23,24,25, Bedell BA26, Rossi RM25,27, Skogstrand K2,28, Peng S29,30, Thompson WK2,3, Appadurai V2,3, Lawlor DA21,22,31, Kalliala I32,33, Power C34, McCarthy MI7,35,36, Boyd HA1, Marazita ML37,38, Hakonarson H8,39,40, Hayes MG10,41,42, Scholtens DM43, Rivadeneira F11,13,44, Jaddoe VWV11,12,13, Vinding RK17, Bisgaard H17, Knight BA45, Pahkala K18,46, Raitakari O18,47, Helgeland Ø48,49,50, Johansson S48,51, Njølstad PR48,49, Fadista J1,52, Schork AJ2,3, Nudel R2,3, Miller DE53, Chen X53, Weirauch MT27,53,54, Mortensen PB2,55,56, Børglum AD2,56,57, Nordentoft M2,58,59, Mors O2,60, Hao K29,30, Ryckman KK26,61, Hougaard DM2,28, Kottyan LC27,53, Pennell CE19, Lyytikainen LP62,63, Bønnelykke K17, Vrijheid M14,15,16, Felix JF11,12,13, Lowe WL Jr10, Grant SFA8,39,40, Hyppönen E34,64,65, Jacobsson B6,66, Jarvelin MR67,68, Muglia LJ23,24,26,27, Murray JC26, Freathy RM4,69, Werge TM2,3,59, Melbye M1,59,70, Buil A2,3, Feenstra B71.

 

Nat Commun. 2019 Sep 2;10(1):3927.

doi: 10.1038/s41467-019-11881-8.

PMID: 31477735

The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 Diabetes.

PMID: 31409726

A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

Jonathan P Bradfield,  Suzanne Vogelezang,  Janine F Felix,  Alessandra Chesi, Øyvind Helgeland,  Momoko Horikoshi,  Ville Karhunen,  Estelle Lowry,  Diana L Cousminer, Tarunveer S Ahluwalia,  Elisabeth Thiering,  Eileen Tai-Hui Boh,  Mohammad H Zafarmand, Natalia Vilor-Tejedor,  Carol A Wang,  Raimo Joro,  Zhanghua Chen,  William J Gauderman, Niina Pitkänen,  Esteban J Parra,  Lindsay Fernandez-Rhodes,  Akram Alyass, Claire Monnereau,  John A Curtin,  Christian T Have,  Shana E McCormack, Mette Hollensted,  Christine Frithioff-Bøjsøe,  Adan Valladares-Salgado, Jesus Peralta-Romero,  Yik-Ying Teo,  Marie Standl,  Jaakko T Leinonen, Jens-Christian Holm,  Triinu Peters,  Jesus Vioque,  Martine Vrijheid,  Angela Simpson, Adnan Custovic,  Marc Vaudel,  Mickaël Canouil,  Virpi Lindi,  Mustafa Atalay,  Mika Kähönen, Olli T Raitakari,  Barbera D C van Schaik,  Robert I Berkowitz,  Shelley A Cole, V Saroja Voruganti,  Yujie Wang,  Heather M Highland,  Anthony G Comuzzie,  Nancy F Butte, Anne E Justice,  Sheila Gahagan,  Estela Blanco,  Terho Lehtimäki,  Timo A Lakka, Johannes Hebebrand,  Amélie Bonnefond,  Niels Grarup,  Philippe Froguel, Leo-Pekka Lyytikäinen,  Miguel Cruz,  Sayuko Kobes,  Robert L Hanson,  Babette S Zemel, Anke Hinney,  Koon K Teo,  David Meyre,  Kari E North,  Frank D Gilliland,  Hans Bisgaard, Mariona Bustamante,  Klaus Bonnelykke,  Craig E Pennell,  Fernando Rivadeneira, André G Uitterlinden,  Leslie J Baier,  Tanja G M Vrijkotte,  Joachim Heinrich, Thorkild I A Sørensen,  Seang-Mei Saw,  Oluf Pedersen,  Torben Hansen,  Johan Eriksson, Elisabeth Widén,  Mark I McCarthy,  Pål R Njølstad,  Christine Power,  Elina Hyppönen, Sylvain Sebert,  Christopher D Brown,  Marjo-Riitta Järvelin,  Nicholas J Timpson, Stefan Johansson,  Hakon Hakonarson,  Vincent W V Jaddoe,  Struan F A Grant, for the Early Growth Genetics Consortium

 

Human Molecular Genetics, ddz161, 05 July 2019.

PMID: LINK

Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver.

Çalışkan M, Manduchi E, Rao HS, Segert JA, Beltrame MH, Trizzino M, Park Y, Baker SW, Chesi A, Johnson ME, Hodge KM, Leonard ME, Loza B, Xin D, Berrido AM, Hand NJ, Bauer RC, Wells AD, Olthoff KM, Shaked A, Rader DJ, Grant SFA, Brown CD.

Am J Hum Genet. 2019 Jul 3;105(1):89-107.

PMID: 31204013

Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study.

Fu J, Wang Y, Li G, Han L, Li Y, Li L, Feng D, Wu Y, Xiao X, Li M, Grant SFA, Li M, Gao S.

International Journal of Obesity, volume 43, pages1556–1567 (2019)

PMID: 31285522

Intersections and clinical translations of diabetes mellitus with cancer promotion, progression and prognosis.

Schwartz SS, Grant SFA, Herman ME.

Postgraduate Medicine, 2019.

PMID: 31419922

T follicular helper cells in human efferent lymph retain lymphoid characteristics

Vella LA, Buggert M, Manne S, Herati RS, Sayin I, Kuri-Cervantes L, Bukh Brody I, O'Boyle KC, Kaprielian H, Giles JR, Nguyen S, Muselman A, Antel JP, Bar-Or A, Johnson ME, Canaday DH, Naji A, Ganusov VV, Laufer TM, Wells AD, Dori Y, Itkin MG, Betts MR, Wherry EJ.

J Clin Invest. 2019;129(8):3185–3200.

PMID: 31264971

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi, Felix R. Day, Øyvind Helgeland, Charles Laurin, Jonas Bacelis, Shouneng Peng, Ke Hao, Bjarke Feenstra, Andrew R. Wood, Anubha Mahajan, Jessica Tyrrell, Neil R. Robertson, N. William Rayner, Zhen Qiao, Gunn-Helen Moen, Marc Vaudel, Carmen J. Marsit, Jia Chen, Michael Nodzenski, Theresia M. Schnurr, Mohammad H. Zafarmand, Jonathan P. Bradfield, Niels Grarup, Marjolein N. Kooijman, Ruifang Li-Gao, Frank Geller, Tarunveer S. Ahluwalia, Lavinia Paternoster, Rico Rueedi, Ville Huikari, Jouke-Jan Hottenga, Leo-Pekka Lyytikäinen, Alana Cavadino, Sarah Metrustry, Diana L. Cousminer, Ying Wu, Elisabeth Thiering, Carol A. Wang, Christian T. Have, Natalia Vilor-Tejedor, Peter K. Joshi, Jodie N. Painter, Ioanna Ntalla, Ronny Myhre, Niina Pitkänen, Elisabeth M. van Leeuwen, Raimo Joro, Vasiliki Lagou, Rebecca C. Richmond, Ana Espinosa, Sheila J. Barton, Hazel M. Inskip, John W. Holloway, Loreto Santa-Marina, Xavier Estivill, Wei Ang, Julie A. Marsh, Christoph Reichetzeder, Letizia Marullo, Berthold Hocher, Kathryn L. Lunetta, Joanne M. Murabito, Caroline L. Relton, Manolis Kogevinas, Leda Chatzi, Catherine Allard, Luigi Bouchard, Marie-France Hivert, Ge Zhang, Louis J. Muglia, Jani Heikkinen, EGG Consortium, Camilla S. Morgen, Antoine H. C. van Kampen, Barbera D. C. van Schaik, Frank D. Mentch, Claudia Langenberg, Jian’an Luan, Robert A. Scott, Jing Hua Zhao, Gibran Hemani, Susan M. Ring, Amanda J. Bennett, Kyle J. Gaulton, Juan Fernandez-Tajes, Natalie R. van Zuydam, Carolina Medina-Gomez, Hugoline G. de Haan, Frits R. Rosendaal, Zoltán Kutalik, Pedro Marques-Vidal, Shikta Das, Gonneke Willemsen, Hamdi Mbarek, Martina Müller-Nurasyid, Marie Standl, Emil V. R. Appel, Cilius E. Fonvig, Caecilie Trier, Catharina E. M. van Beijsterveldt, Mario Murcia, Mariona Bustamante, Sílvia Bonas-Guarch, David M. Hougaard, Josep M. Mercader, Allan Linneberg, Katharina E. Schraut, Penelope A. Lind, Sarah E. Medland, Beverley M. Shields, Bridget A. Knight, Jin-Fang Chai, Kalliope Panoutsopoulou, Meike Bartels, Friman Sánchez, Jakob Stokholm, David Torrents, Rebecca K. Vinding, Sara M. Willems, Mustafa Atalay, Bo L. Chawes, Peter Kovacs, Inga Prokopenko, Marcus A. Tuke, Hanieh Yaghootkar, Katherine S. Ruth, Samuel E. Jones, Po-Ru Loh, Anna Murray, Michael N. Weedon, Anke Tönjes, Michael Stumvoll, Kim F. Michaelsen, Aino-Maija Eloranta, Timo A. Lakka, Cornelia M. van Duijn, Wieland Kiess, Antje Körner, Harri Niinikoski, Katja Pahkala, Olli T. Raitakari, Bo Jacobsson, Eleftheria Zeggini, George V. Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Grant W. Montgomery, Harry Campbell, James F. Wilson, Tanja G. M. Vrijkotte, Martine Vrijheid, Eco J. C. N. de Geus, M. Geoffrey Hayes, Haja N. Kadarmideen, Jens-Christian Holm, Lawrence J. Beilin, Craig E. Pennell, Joachim Heinrich, Linda S. Adair, Judith B. Borja, Karen L. Mohlke, Johan G. Eriksson, Elisabeth E. Widén, Andrew T. Hattersley, Tim D. Spector, Mika Kähönen, Jorma S. Viikari, Terho Lehtimäki, Dorret I. Boomsma, Sylvain Sebert, Peter Vollenweider, Thorkild I. A. Sørensen, Hans Bisgaard, Klaus Bønnelykke, Jeffrey C. Murray, Mads Melbye, Ellen A. Nohr, Dennis O. Mook-Kanamori, Fernando Rivadeneira, Albert Hofman, Janine F. Felix, Vincent W. V. Jaddoe, Torben Hansen, Charlotta Pisinger, Allan A. Vaag, Oluf Pedersen, André G. Uitterlinden, Marjo-Riitta Järvelin, Christine Power, Elina Hyppönen, Denise M. Scholtens, William L. Lowe Jr, George Davey Smith, Nicholas J. Timpson, Andrew P. Morris, Nicholas J. Wareham, Hakon Hakonarson, Struan F. A. Grant, Timothy M. Frayling, Debbie A. Lawlor, Pål R. Njølstad, Stefan Johansson, Ken K. Ong, Mark I. McCarthy, John R. B. Perry, David M. Evans & Rachel M. Freathy

Nature Genetics 51, 804–814 (2019)

PMID: 31043758

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bonemineral density

Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F.A. Grant

NATURE COMMUNICATIONS | (2019)10:1260

PMID: 30890710

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