Spatial & Functional
Genomics Affinity Group

SFG Publications

The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 Diabetes.

PMID: 31409726

A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

Jonathan P Bradfield,  Suzanne Vogelezang,  Janine F Felix,  Alessandra Chesi, Øyvind Helgeland,  Momoko Horikoshi,  Ville Karhunen,  Estelle Lowry,  Diana L Cousminer, Tarunveer S Ahluwalia,  Elisabeth Thiering,  Eileen Tai-Hui Boh,  Mohammad H Zafarmand, Natalia Vilor-Tejedor,  Carol A Wang,  Raimo Joro,  Zhanghua Chen,  William J Gauderman, Niina Pitkänen,  Esteban J Parra,  Lindsay Fernandez-Rhodes,  Akram Alyass, Claire Monnereau,  John A Curtin,  Christian T Have,  Shana E McCormack, Mette Hollensted,  Christine Frithioff-Bøjsøe,  Adan Valladares-Salgado, Jesus Peralta-Romero,  Yik-Ying Teo,  Marie Standl,  Jaakko T Leinonen, Jens-Christian Holm,  Triinu Peters,  Jesus Vioque,  Martine Vrijheid,  Angela Simpson, Adnan Custovic,  Marc Vaudel,  Mickaël Canouil,  Virpi Lindi,  Mustafa Atalay,  Mika Kähönen, Olli T Raitakari,  Barbera D C van Schaik,  Robert I Berkowitz,  Shelley A Cole, V Saroja Voruganti,  Yujie Wang,  Heather M Highland,  Anthony G Comuzzie,  Nancy F Butte, Anne E Justice,  Sheila Gahagan,  Estela Blanco,  Terho Lehtimäki,  Timo A Lakka, Johannes Hebebrand,  Amélie Bonnefond,  Niels Grarup,  Philippe Froguel, Leo-Pekka Lyytikäinen,  Miguel Cruz,  Sayuko Kobes,  Robert L Hanson,  Babette S Zemel, Anke Hinney,  Koon K Teo,  David Meyre,  Kari E North,  Frank D Gilliland,  Hans Bisgaard, Mariona Bustamante,  Klaus Bonnelykke,  Craig E Pennell,  Fernando Rivadeneira, André G Uitterlinden,  Leslie J Baier,  Tanja G M Vrijkotte,  Joachim Heinrich, Thorkild I A Sørensen,  Seang-Mei Saw,  Oluf Pedersen,  Torben Hansen,  Johan Eriksson, Elisabeth Widén,  Mark I McCarthy,  Pål R Njølstad,  Christine Power,  Elina Hyppönen, Sylvain Sebert,  Christopher D Brown,  Marjo-Riitta Järvelin,  Nicholas J Timpson, Stefan Johansson,  Hakon Hakonarson,  Vincent W V Jaddoe,  Struan F A Grant, for the Early Growth Genetics Consortium

 

Human Molecular Genetics, ddz161, 05 July 2019.

PMID: LINK

Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver.

Çalışkan M, Manduchi E, Rao HS, Segert JA, Beltrame MH, Trizzino M, Park Y, Baker SW, Chesi A, Johnson ME, Hodge KM, Leonard ME, Loza B, Xin D, Berrido AM, Hand NJ, Bauer RC, Wells AD, Olthoff KM, Shaked A, Rader DJ, Grant SFA, Brown CD.

Am J Hum Genet. 2019 Jul 3;105(1):89-107.

PMID: 31204013

Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study.

Fu J, Wang Y, Li G, Han L, Li Y, Li L, Feng D, Wu Y, Xiao X, Li M, Grant SFA, Li M, Gao S.

International Journal of Obesity, volume 43, pages1556–1567 (2019)

PMID: 31285522

Intersections and clinical translations of diabetes mellitus with cancer promotion, progression and prognosis.

Schwartz SS, Grant SFA, Herman ME.

Postgraduate Medicine, 2019.

PMID: 31419922

T follicular helper cells in human efferent lymph retain lymphoid characteristics

Vella LA, Buggert M, Manne S, Herati RS, Sayin I, Kuri-Cervantes L, Bukh Brody I, O'Boyle KC, Kaprielian H, Giles JR, Nguyen S, Muselman A, Antel JP, Bar-Or A, Johnson ME, Canaday DH, Naji A, Ganusov VV, Laufer TM, Wells AD, Dori Y, Itkin MG, Betts MR, Wherry EJ.

J Clin Invest. 2019;129(8):3185–3200.

PMID: 31264971

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi, Felix R. Day, Øyvind Helgeland, Charles Laurin, Jonas Bacelis, Shouneng Peng, Ke Hao, Bjarke Feenstra, Andrew R. Wood, Anubha Mahajan, Jessica Tyrrell, Neil R. Robertson, N. William Rayner, Zhen Qiao, Gunn-Helen Moen, Marc Vaudel, Carmen J. Marsit, Jia Chen, Michael Nodzenski, Theresia M. Schnurr, Mohammad H. Zafarmand, Jonathan P. Bradfield, Niels Grarup, Marjolein N. Kooijman, Ruifang Li-Gao, Frank Geller, Tarunveer S. Ahluwalia, Lavinia Paternoster, Rico Rueedi, Ville Huikari, Jouke-Jan Hottenga, Leo-Pekka Lyytikäinen, Alana Cavadino, Sarah Metrustry, Diana L. Cousminer, Ying Wu, Elisabeth Thiering, Carol A. Wang, Christian T. Have, Natalia Vilor-Tejedor, Peter K. Joshi, Jodie N. Painter, Ioanna Ntalla, Ronny Myhre, Niina Pitkänen, Elisabeth M. van Leeuwen, Raimo Joro, Vasiliki Lagou, Rebecca C. Richmond, Ana Espinosa, Sheila J. Barton, Hazel M. Inskip, John W. Holloway, Loreto Santa-Marina, Xavier Estivill, Wei Ang, Julie A. Marsh, Christoph Reichetzeder, Letizia Marullo, Berthold Hocher, Kathryn L. Lunetta, Joanne M. Murabito, Caroline L. Relton, Manolis Kogevinas, Leda Chatzi, Catherine Allard, Luigi Bouchard, Marie-France Hivert, Ge Zhang, Louis J. Muglia, Jani Heikkinen, EGG Consortium, Camilla S. Morgen, Antoine H. C. van Kampen, Barbera D. C. van Schaik, Frank D. Mentch, Claudia Langenberg, Jian’an Luan, Robert A. Scott, Jing Hua Zhao, Gibran Hemani, Susan M. Ring, Amanda J. Bennett, Kyle J. Gaulton, Juan Fernandez-Tajes, Natalie R. van Zuydam, Carolina Medina-Gomez, Hugoline G. de Haan, Frits R. Rosendaal, Zoltán Kutalik, Pedro Marques-Vidal, Shikta Das, Gonneke Willemsen, Hamdi Mbarek, Martina Müller-Nurasyid, Marie Standl, Emil V. R. Appel, Cilius E. Fonvig, Caecilie Trier, Catharina E. M. van Beijsterveldt, Mario Murcia, Mariona Bustamante, Sílvia Bonas-Guarch, David M. Hougaard, Josep M. Mercader, Allan Linneberg, Katharina E. Schraut, Penelope A. Lind, Sarah E. Medland, Beverley M. Shields, Bridget A. Knight, Jin-Fang Chai, Kalliope Panoutsopoulou, Meike Bartels, Friman Sánchez, Jakob Stokholm, David Torrents, Rebecca K. Vinding, Sara M. Willems, Mustafa Atalay, Bo L. Chawes, Peter Kovacs, Inga Prokopenko, Marcus A. Tuke, Hanieh Yaghootkar, Katherine S. Ruth, Samuel E. Jones, Po-Ru Loh, Anna Murray, Michael N. Weedon, Anke Tönjes, Michael Stumvoll, Kim F. Michaelsen, Aino-Maija Eloranta, Timo A. Lakka, Cornelia M. van Duijn, Wieland Kiess, Antje Körner, Harri Niinikoski, Katja Pahkala, Olli T. Raitakari, Bo Jacobsson, Eleftheria Zeggini, George V. Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Grant W. Montgomery, Harry Campbell, James F. Wilson, Tanja G. M. Vrijkotte, Martine Vrijheid, Eco J. C. N. de Geus, M. Geoffrey Hayes, Haja N. Kadarmideen, Jens-Christian Holm, Lawrence J. Beilin, Craig E. Pennell, Joachim Heinrich, Linda S. Adair, Judith B. Borja, Karen L. Mohlke, Johan G. Eriksson, Elisabeth E. Widén, Andrew T. Hattersley, Tim D. Spector, Mika Kähönen, Jorma S. Viikari, Terho Lehtimäki, Dorret I. Boomsma, Sylvain Sebert, Peter Vollenweider, Thorkild I. A. Sørensen, Hans Bisgaard, Klaus Bønnelykke, Jeffrey C. Murray, Mads Melbye, Ellen A. Nohr, Dennis O. Mook-Kanamori, Fernando Rivadeneira, Albert Hofman, Janine F. Felix, Vincent W. V. Jaddoe, Torben Hansen, Charlotta Pisinger, Allan A. Vaag, Oluf Pedersen, André G. Uitterlinden, Marjo-Riitta Järvelin, Christine Power, Elina Hyppönen, Denise M. Scholtens, William L. Lowe Jr, George Davey Smith, Nicholas J. Timpson, Andrew P. Morris, Nicholas J. Wareham, Hakon Hakonarson, Struan F. A. Grant, Timothy M. Frayling, Debbie A. Lawlor, Pål R. Njølstad, Stefan Johansson, Ken K. Ong, Mark I. McCarthy, John R. B. Perry, David M. Evans & Rachel M. Freathy

Nature Genetics 51, 804–814 (2019)

PMID: 31043758

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bonemineral density

Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F.A. Grant

NATURE COMMUNICATIONS | (2019)10:1260

PMID: 30890710

Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls

Diana L. Cousminer, Shana E. McCormack, Jonathan A. Mitchell, Alessandra Chesi, Joseph M. Kindler, Andrea Kelly, Benjamin F. Voight, Heidi J. Kalkwarf, Joan M. Lappe, John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel, Struan F.A. Grant

Bone, 2019.01.026

PMID: 30711642

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC.
Cell. 2018 Oct 30. pii: S0092-8674(18)31309-6. doi: 10.1016/j.cell.2018.10.001. [Epub ahead of print]

PMID: 30392958

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