Genome-scale Capture C promoter interaction analysis implicates novel effector genes at lipid GWAS loci. Elisabetta Manduchi, Alessandra Chesi, Chun Su, Michelle E. Leonard, Sumei Lu, Kenyaita M. Hodge, James A. Pippin, Robert C. Bauer, Matthew E. Johnson, Andrew D. Wells, and Struan F. A. Grant. Moderated Poster. November 10th-12th, 2018. Chicago, IL., USA
Genome-scale capture C promoter interaction analysis implicates novel effector genes at GWAS loci for bone mineral density. A. Chesi, Y. Wagley, M.E. Johnson, M. Manduchi, C. Su, S. Lu, M.E. Leonard, K.M. Hodge, J.A. Pippin, K.D. Hankenson, A.D. Wells, S.F.A. Grant. Plenary talk. October 16th-20th, 2018. San Diego, CA., USA
Genetic study of longitudinal pubertal height growth describes links with adult health. D. Cousminer, Early Growth Genetics (EGG) Consortium. Platform Presentation. October 16th-20th, 2018. San Diego, CA., USA
Diana Cousminer, PhD, Division of Human Genetics (CHOP); Title: Identifying biomarkers of adverse health in early and late puberty using a computational ‘multiomics’ approach.
Complex diseases are associated with genetic, environmental, and lifestyle factors. Genome-wide association studies, or GWAS, use arrays to identify DNA variants associated with traits or diseases. Professors Struan Grant and Andrew Wells of the Children's Hospital of Philadelphia discuss how they use NGS to map variants to causal genes.
A high-resolution, genome-scale promoter interactome in human T follicular helper cells implicates novel causal genes at SLE GWAS loci. Oral Presentation. May 4-8, 2018, Austin, TX. USA
A high resolution Capture-C promoter 'interactome' implicates causal genes at BMD GWAS loci. Plenary Oral Presentation. May 26 - 29, 2018, Valencia, Spain
A high-resolution, genome-scale promoter 'interactome' in human T follicular helper cells implicates novel effector genes at SLE GWAS loci. Oral Presentation. June 16-19, 2018, Milan, Italy.
CRISPR/Cas9 mediated deletion of a proxy 19.2kb distal to the T2D GWAS-implicated SLC30A8 R325W variant impacts RAD21 and UTP23 gene expression in HepG2 cells. Poster. June 22-26, 2018, Orlando, FL USA