Spatial & Functional
Genomics Affinity Group


Long-Term Study Finds Dozens of New Genetic Markers Associated with Lifetime Bone Growth

A multidisciplinary team of researchers led by Children’s Hospital of Philadelphia (CHOP) has discovered several genetic markers associated with bone mineral accrual, which could ultimately help identify causes of eventual osteoporosis earlier in life through genetic testing. The findings, which were made possible by following a group of children over several years, were published online by the journal Genome Biology.

Genetic differences help distinguish type 1 diabetes in children from 'type 1.5' in adults.

Philadelphia, January, 2020--A multi-center team of researchers led by Children's Hospital of Philadelphia (CHOP) has discovered a genetic signature that could help distinguish an adult-onset form of diabetes sharing many type 1 diabetes (T1D) characteristics from pediatric-onset T1D, opening the door to potentially more straightforward diagnostic tests for the adult condition and improving responses by ensuring patients receive the most appropriate treatment. --EurekAlert! - AAAS

Inflammatory bowel disease genetically tied to stress, depression, CHOP finds

Researchers at the Children's Hospital of Philadelphia have confirmed a connection between inflammatory bowel disease and stress and depression by using 3D genetic mapping. --Philly Voice

3-D Genome Mapping Uncovers Possible Treatment Targets in Lupus

A new method of mapping the genome in 3-D led researchers at Children’s Hospital of Philadelphia to discover two kinases that play a role in systemic lupus erythematosus, which now are potential treatment targets for the disease.

2019 ASHG C.W. Cotterman Award

Congratulations to Minal Çalışkan on winning the Cotterman Award at the 2019 ASHG Meeting for "Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver". Delighted to have contributed to the study!

Michigan Health: New Study Identifies Causative Genes in Osteoporosis

Researchers identified two novel genes that affect bone-formation cells relevant to fractures and osteoporosis; understanding these genes could lead to more effective treatments.