Spatial & Functional
Genomics Affinity Group

SFG Grants

Variant to Gene Mapping for Alzheimer's Disease

NIA
PI: S. Grant
09/15/2017 to 06/30/2022

R01 AG057516

Treating Chronic Viral Infection by Epigenetic Reprogramming of Exhausted CD8 T Cells

PI: Shen
09/01/2017 to 08/31/2022

R01 AI130115

Role: Co-Investigator

The major goal of this project is to study how pharmacologic histone deacetylase inhibitors reprogram exhausted CD8 T cells at the epigenomic, transcriptional, and function level. These studies do not overlap with any of the other listed projects.

Epigenetic Imprinting of Follicular Helper T Cell Fate and Function in Lupus

NIH/NIAID
PI: Laufer
09/01/2017 to 08/31/2022

R01 AI123539

Role: Co-Investigator

The major goal of this project is to establish the epigenetic mechanisms involved in the Tfh cell fate decision, and whether these processes are dysregulated in individuals genetically susceptible to lupus. These studies do not overlap with any of the other listed projects.

TCF7L2, ACSL5 and Lipid Mediators in CF-Related Diabetes

CF Foundation
PI: R. Rubenstein
10/01/2016 to 09/30/2019

RUBENS16A0

Role: Co-Investigator (S. Grant)

Variant to Gene Mapping for Type 2 Diabetes

NICHD
PI: S. Grant
07/01/2016 to 06/30/2019

R21 HD089824

Cyclin-dependent Kinases: Novel Switches in Anergy and Targets for Tolerance

NIH/NIAID
PI: A. Wells
12/01/2015 to 11/30/2020

R01 AI054643-12

The major goal of this project is to determine the mechanisms by which CDK influence T cell memory vs. tolerance, and to test these enzymes as therapeutic targets in transplantation models.

Exploiting Metabolic Vulnerabilities of CD4+ T Cell Subsets to Control Inflammation

NIH/NIDDK
PI: J. Rathmell
05/01/2015 to 04/30/2019

R01 DK100901

The major goal of this project is to determine the role of glucose and related metabolic pathways in regulating CD4+ T cell function.

The Myc-Mir-17-92 Axis in Colorectal Cancers

NCI
PI: A. Thomas-Tikhonenko
04/01/2015 to 03/31/2020

R01 CA196299

Role: Co-Investigator (S. Grant)

Intergenic cis-Regulatory Elements in the Control of IL-2 and IL-21

NIH/NIAID
PI: A. Wells
01/01/2014 to 11/30/2017

R21 AI110179-01

Role: Collaborator

The major goal of this project is to identify distal enhancer elements that regulate transcription of the IL-2 and IL-21 genes using ChIP and 3-dimensional chromosome capture approaches.

Genome Wide Association Study of Latent Autoimmune Diabetes in Adults

NIDDK
PI: S. Grant
07/01/2011 to 03/31/2019

R01 DK085212

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