SFG Grants
Variant to Gene Mapping for Alzheimer's Disease
NIA
PI: S. Grant
09/15/2017 to 06/30/2022
Treating Chronic Viral Infection by Epigenetic Reprogramming of Exhausted CD8 T Cells
PI: Shen
09/01/2017 to 08/31/2022
Role: Co-Investigator
The major goal of this project is to study how pharmacologic histone deacetylase inhibitors reprogram exhausted CD8 T cells at the epigenomic, transcriptional, and function level. These studies do not overlap with any of the other listed projects.
Epigenetic Imprinting of Follicular Helper T Cell Fate and Function in Lupus
NIH/NIAID
PI: Laufer
09/01/2017 to 08/31/2022
Role: Co-Investigator
The major goal of this project is to establish the epigenetic mechanisms involved in the Tfh cell fate decision, and whether these processes are dysregulated in individuals genetically susceptible to lupus. These studies do not overlap with any of the other listed projects.
TCF7L2, ACSL5 and Lipid Mediators in CF-Related Diabetes
CF Foundation
PI: R. Rubenstein
10/01/2016 to 09/30/2019
Role: Co-Investigator (S. Grant)
Variant to Gene Mapping for Type 2 Diabetes
NICHD
PI: S. Grant
07/01/2016 to 06/30/2019
Cyclin-dependent Kinases: Novel Switches in Anergy and Targets for Tolerance
NIH/NIAID
PI: A. Wells
12/01/2015 to 11/30/2020
The major goal of this project is to determine the mechanisms by which CDK influence T cell memory vs. tolerance, and to test these enzymes as therapeutic targets in transplantation models.
Exploiting Metabolic Vulnerabilities of CD4+ T Cell Subsets to Control Inflammation
NIH/NIDDK
PI: J. Rathmell
05/01/2015 to 04/30/2019
The major goal of this project is to determine the role of glucose and related metabolic pathways in regulating CD4+ T cell function.
The Myc-Mir-17-92 Axis in Colorectal Cancers
NCI
PI: A. Thomas-Tikhonenko
04/01/2015 to 03/31/2020
Role: Co-Investigator (S. Grant)
Intergenic cis-Regulatory Elements in the Control of IL-2 and IL-21
NIH/NIAID
PI: A. Wells
01/01/2014 to 11/30/2017
Role: Collaborator
The major goal of this project is to identify distal enhancer elements that regulate transcription of the IL-2 and IL-21 genes using ChIP and 3-dimensional chromosome capture approaches.