Spatial & Functional
Genomics Affinity Group

SFG Grants

Implicating novel microglial mechanisms of late-onset Alzheimer’s disease with variant-to-gene mapping methods.

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
PI: Elizabeth A. Burton
09/01/2021 to 09/01/2024

FAG074532A

Role: Predoctoral Fellowship

Cosponsors: Struan F.A. Grant & Christopher D. Brown

Project Consultant: Li-San Wang

FUNCTIONAL INTERROGATION OF T2D-ASSOCIATED GENES IN HUMAN STEM CELL-DERIVED MODELS AND MICE

NIH
PI: Patrick Seale, Struan Grant, Klaus Kaestner, Daniel Rader, Benjamin Voight, Wenli Yang
08/20/2020 to 06/30/2025

UM1 DK126194-01

GENOMICS OF BONE AND BODY COMPOSITION TRAITS IN CHILDREN

NIH
PI: Babette Zemel and Struan Grant
08/07/2020 to 06/30/2025

R01 HD100406-01A1

GENOME WIDE ASSOCIATION STUDY FOR CHILDHOOD OBESITY

NIH
PI: Struan F. A. Grant
07/15/2008 to 06/30/2025

R01 HD056465-11A1

Promoter interactome-aided mapping of unexplored CVID genetic landscapes

NIAID
PI: N. Romberg
07/16/2019 to 06/30/2024

R01 AI146026

Role: Co-Investigator

Functional Mechanisms of T1D Risk Variants and their Target Genes using 3D Epigenomics and Single Cell Approaches

NIDDK
PI: S. Grant, S. Rich, A. Wells
08/01/2019 to 05/31/2023

R01 DK122586

Network-based algorithms for drug discovery from genetic associations

NHGRI
PI: C Greene
06/12/2018 to 04/30/2023

R01 HG010067

Role: Co-Investigator

Treating Chronic Viral Infection by Epigenetic Reprogramming of Exhausted CD8 T Cells

PI: Shen
09/01/2017 to 08/31/2022

R01 AI130115

Role: Co-Investigator

The major goal of this project is to study how pharmacologic histone deacetylase inhibitors reprogram exhausted CD8 T cells at the epigenomic, transcriptional, and function level. These studies do not overlap with any of the other listed projects.

Epigenetic Imprinting of Follicular Helper T Cell Fate and Function in Lupus

NIH/NIAID
PI: Laufer
09/01/2017 to 08/31/2022

R01 AI123539

Role: Co-Investigator

The major goal of this project is to establish the epigenetic mechanisms involved in the Tfh cell fate decision, and whether these processes are dysregulated in individuals genetically susceptible to lupus. These studies do not overlap with any of the other listed projects.

Elucidation of Genetic Effects on Sleep and Circadian Traits

NHLBI
PI: P. Gehrman, S. Grant, A. Keene
09/01/2018 to 06/30/2022

R01 HL143790

Integrating GWAS of Sleep and Circadian Traits with functional follow-up efforts

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