Spatial & Functional
Genomics Affinity Group

SFG Grants

Promoter interactome-aided mapping of unexplored CVID genetic landscapes

NIAID
PI: N. Romberg
07/16/2019 to 06/30/2024

R01 AI146026

Role: Co-Investigator

Functional Mechanisms of T1D Risk Variants and their Target Genes using 3D Epigenomics and Single Cell Approaches

NIDDK
PI: S. Grant, S. Rich, A. Wells
08/01/2019 to 05/31/2023

R01 DK122586

Network-based algorithms for drug discovery from genetic associations

NHGRI
PI: C Greene
06/12/2018 to 04/30/2023

R01 HG010067

Role: Co-Investigator

Treating Chronic Viral Infection by Epigenetic Reprogramming of Exhausted CD8 T Cells

PI: Shen
09/01/2017 to 08/31/2022

R01 AI130115

Role: Co-Investigator

The major goal of this project is to study how pharmacologic histone deacetylase inhibitors reprogram exhausted CD8 T cells at the epigenomic, transcriptional, and function level. These studies do not overlap with any of the other listed projects.

Epigenetic Imprinting of Follicular Helper T Cell Fate and Function in Lupus

NIH/NIAID
PI: Laufer
09/01/2017 to 08/31/2022

R01 AI123539

Role: Co-Investigator

The major goal of this project is to establish the epigenetic mechanisms involved in the Tfh cell fate decision, and whether these processes are dysregulated in individuals genetically susceptible to lupus. These studies do not overlap with any of the other listed projects.

Elucidation of Genetic Effects on Sleep and Circadian Traits

NHLBI
PI: P. Gehrman, S. Grant, A. Keene
09/01/2018 to 06/30/2022

R01 HL143790

Integrating GWAS of Sleep and Circadian Traits with functional follow-up efforts

Variant to Gene Mapping for Alzheimer's Disease

NIA
PI: S. Grant
09/15/2017 to 06/30/2022

R01 AG057516

Decoding Methylation Mediated Epigenomic Contributions to Male Osteoporosis

NIAMS
PI: H.W. Deng
09/01/2006 to 08/31/2021

R01 AR069055

Role: Role: Co-Investigator (S. Grant)

Cyclin-dependent Kinases: Novel Switches in Anergy and Targets for Tolerance

NIH/NIAID
PI: A. Wells
12/01/2015 to 11/30/2020

R01 AI054643-12

The major goal of this project is to determine the mechanisms by which CDK influence T cell memory vs. tolerance, and to test these enzymes as therapeutic targets in transplantation models.

Regulation of Skeletal Growth by Nuclear Retinoid Receptors

NIH/NIAMS
PI: M. Iwamoto
12/01/2008 to 08/31/2020

R01 AR056837

Role: Co-Investigator (S. Grant)

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