Spatial & Functional
Genomics Affinity Group

Neurologic disease

Genome wide association studies (GWAS) have clearly revolutionized the field of complex disease genetics, where intense efforts by large-scale international collaborations have been successful in discovering key genetic variants robustly associated with Alzheimer's disease (AD). However, GWAS only reports genomic signals associated with a given trait and not necessarily the precise localization of culprit genes. Given the need for 'variant to gene mapping', plus the need to expand the collection of public domain genomic data relevant to brain tissue types, we are NIH funded to utilize '3D Genomic' and CRISPR based screens in iPSC-derived cell types to pinpoint the causal gene(s) at each key AD GWAS-implicated locus. We are going on to extend our approach to other neurological conditions that range from insomnia to schizophrenia.