Spatial & Functional
Genomics Affinity Group

Spatial and Functional Genomics

The recent formation of the Center of Spatial and Functional Genomics has positioned over two decades of experience in locus discovery and GWAS in both academic and biotech settings (Struan Grant) and regulation of immunity and inflammatory gene expression (Andrew Wells) to make significant advances in the genetics of common diseases through the application of '3D Genomics' based techniques, including three-dimensional chromosome conformation capture (including genome-wide promoter-focussed Capture C), CRISPR/CAS9 genome editing, ChIP-seq, ATAC-seq, and RNA-seq. This work is already establishing the transcriptional architecture of loci implicated in the genetic susceptibility to disease, and we are now applying these approaches at the whole-genome level in multiple human primary cells and tissues.